Epidemiology

Download e-book for iPad: Applied Statistical Genetics with R: For Population-based by Andrea S. Foulkes

By Andrea S. Foulkes

ISBN-10: 038789554X

ISBN-13: 9780387895543

The gigantic array of molecular point info now on hand offers interesting possibilities to represent the genetic underpinnings of complicated illnesses whereas getting to know novel organic pathways to ailment development. during this introductory graduate point textual content, Dr. Foulkes elucidates middle options that undergird the wide variety of analytic suggestions and software program instruments for the research of knowledge derived from population-based genetic investigations. utilized Statistical Genetics with R deals a transparent and cogent presentation of numerous basic statistical ways that researchers from a number of disciplines, together with medication, public overall healthiness, epidemiology, information and desktop technology, will locate priceless in exploring this rising box. Couched within the language of biostatistics, this article may be simply followed for public overall healthiness and clinical university curricula.

The textual content covers key genetic facts options and statistical ideas to supply the reader with a robust starting place in tools for candidate gene and genome-wide organization reviews. those comprise equipment for unobservable haplotypic part, a number of checking out changes, and high-dimensional facts research. Emphasis is on research of knowledge bobbing up from reports of unrelated contributors and the capability interaction between genetic components and extra conventional, epidemiological possibility components for ailment. whereas theoretically rigorous, the analytic suggestions are awarded at a degree that may entice researchers and scholars with constrained wisdom of statistical genetics. The textual content assumes the reader has accomplished a primary path in biostatistics, makes use of publicly on hand info units for representation, and offers large examples utilizing the open resource, publicly to be had statistical software program setting R.

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Extra resources for Applied Statistical Genetics with R: For Population-based Association Studies (Use R!)

Sample text

Here nij is the number of individuals in the corresponding cell for i = 1, 2 and j = 1, 2, 3. For example, n11 is the number of individuals in our sample who have disease and express the aa genotype. In this setting, a commonly used measure of association is the odds ratio (OR), defined as the ratio of the odds of disease among the exposed to the odds of disease among the unexposed. In our setting, genotype can be thought of as the exposure, so that the OR is the ratio of the odds of disease given a specific genotype to the odds of disease among individuals without the specified genotype.

1. State the primary analytic considerations that distinguish populationbased and family-based investigations. 2. Define and contrast the following terms: (a) genotype, (b) haplotype, (c) phase, (d) homologous, (e) allele, and (f) zygosity. 3. Based on the FAMuSS data, determine the minor allele and its frequency for the actn3 1671064 SNP. Report these frequencies overall and stratified by the variable labeled Race. Interpret your findings. 4. area. Interpret the results. 5. Report the observed proportion of mutations at sites 1, 10, 30, 71, 82 and 90 in the Protease region of the HIV genome for the Virco data using the variables labeled P1, P10, P30, P71, P82 and P90.

The choice of using cross-sectional or longitudinal data rests primarily on the scientific question at hand. For example, if interest lies in determining whether genotype affects the change in VL after exposure to a specific drug, then a longitudinal design with repeated measures of VL is essential. On the other hand, if the interest is in characterizing VL as a function of genotype at initiation of therapy, then cross-sectional data may be 12 1 Genetic Association Studies sufficient. While longitudinal studies can increase the power to detect association, they tend to be more costly than cross-sectional studies and are more susceptible to missing data and the resulting biases.

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Applied Statistical Genetics with R: For Population-based Association Studies (Use R!) by Andrea S. Foulkes


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