Download e-book for iPad: Advances in Understanding Kingella kingae by Joseph W. St. Geme III

By Joseph W. St. Geme III

ISBN-10: 3319437283

ISBN-13: 9783319437286

ISBN-10: 3319437291

ISBN-13: 9783319437293

This publication describes the becoming physique of knowledge at the epidemiology, scientific manifestations, transmission, pathogenesis, prognosis, and remedy of Kingella kingae infectionsin children. furthermore, it covers experimental tools which were constructed to review the microbiology, genetics, and virulence elements of K. kingae, info that offers the basis for brand spanking new techniques to remedy and prevention of K. kingae disease. With this content material in brain, excerpts from the booklet could be of relevance for clinicians who take care of pediatric sufferers, for medical microbiologists who're all for detecting organisms in scientific specimens, and for scientists who're learning K. kingae in an attempt to strengthen novel ambitions for antimicrobial remedy and new methods to prevention.

First remoted within the Sixties via Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae was once principally missed over the subsequent 20 years as a human pathogen due to its unusual restoration from sufferers with disorder. although, in recent times K. kingae has been more and more well-known as a clinically vital pathogen in kids, and is presently well-known because the best reason behind osteoarticular infections in little ones in an increasing number of international locations. examine into this organism has grown significantly during the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of disorder.

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Representative transmission electron micrographs of negatively stained wild type, pilF mutant, and pilT mutant derivatives of K. kingae strain 269–492 are shown in Fig. 1. Abundant pili are observed emanating from the surface of the wild-type strain (Fig. 1a) and the retraction-deficient pilT mutant (Fig. 1c) but are absent in the pilF assembly mutant (Fig. 1b). K. kingae contains minor pilins called PilA2 and FimB, which are likely incorporated into the pilus fiber but have unclear functions, as elimination of these proteins via deletion of the relevant gene has no effect on type IV pilus phenotypes [2].

1 Transmission electron micrographs of K. kingae strain 269–492 type IV pili surface fibers. a Abundant pili are seen emanating from the surface of wild-type strain 269–492. b Pili are absent from the surface of an isogenic pilF assembly ATPase mutant. c Mutation of the pilT retraction ATPase results in a hyper-piliated phenotype. Bar, 100 nm Pathogenesis of Kingella kingae Disease 31 The adhesive components of the K. kingae type IV pilus are likely the PilC1 and PilC2 pilus-associated proteins, which also play a role in pilus biogenesis [2, 21].

Martin PR, Hobbs M, Free PD, Jeske Y, Mattick JS (1993) Characterization of pilQ, a new gene required for the biogenesis of type 4 fimbriae in Pseudomonas aeruginosa. Mol Microbiol 9(4):857–868 15. Tonjum T, Freitag NE, Namork E, Koomey M (1995) Identification and characterization of pilG, a highly conserved pilus-assembly gene in pathogenic Neisseria. Mol Microbiol 16 (3):451–464 16. Turner LR, Lara JC, Nunn DN, Lory S (1993) Mutations in the consensus ATP-binding sites of XcpR and PilB eliminate extracellular protein secretion and pilus biogenesis in Pseudomonas aeruginosa.

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Advances in Understanding Kingella kingae by Joseph W. St. Geme III

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